PRISMS is dedicated to providing information and support to families of persons with Smith-Magenis Syndrome (SMS), sponsoring research and fostering partnerships with professionals to increase awareness and understanding of SMS.
Newly Diagnosed?
Are you associated with someone who has been newly diagnosed with Smith-Magenis Syndrome?
Become part of the PRISMS community
Sign up to get the latest information and resources from PRISMS and the Smith-Magenis Syndrome community.
Connect with other local families
Connect with your local Regional Representative to help connect you with other SMS families in your area.
You are embarking on a difficult journey, but one that is rewarding.
You will grieve when your child struggles, but you will revel in their accomplishments.
What is SMS?
Smith-Magenis syndrome (SMS) is a rare neurobehavioral disorder characterized by a recognizable pattern of physical, behavioral, and developmental features. It is caused by particular genetic changes on chromosomal region 17p11.2, which contains the gene RAI1. MORE >
What Treatment is Available?
There are no medications that can “cure” SMS or eliminate the core symptoms. However, there are medications that can help some people with SMS function better. For example, medication might help manage high energy levels, inability to focus, or seizures. MORE >
How Rare is SMS?
Although the exact incidence is not known, it is estimated that SMS occurs in about 1/15,000 to 1/25,000 births. SMS is under-diagnosed, but as awareness of the syndrome increases, the number of people identified grows each year. MORE >
How is SMS Diagnosed?
The diagnosis of Smith-Magenis Syndrome (SMS) is usually confirmed through a clinical blood test called a chromosome analysis. Diagnosis can also be made through a cytogenetic test and FISH (fluorescence in situ hybridization) or by chromosome microarray analysis (CGH). MORE >
Please Donate
Our continued efforts depend on donations and gifts from people like you. Won’t you help?
Recent SMS News
A Story of Unexpected Generosity: How One Act of Kindness Changed the Lives of 18 FamiliesLast August, Jessie McClintock’s family found themselves in a desperate situation. Their son, Briggs, who has Smith-Magenis syndrome, was struggling in ways that were not immediately visible to others but were deeply affecting his daily…
See More >
A Nanna’s Love for Her GrandsonBy: Sharon Cook My name is Sharon Cook and I am the Nanna to Skyler, 17, who was diagnosed with SMS at birth. Skyler lives in North Idaho and I live most of the year…
See More >