PRISMS is dedicated to providing information and support to families of persons with Smith-Magenis Syndrome (SMS), sponsoring research and fostering partnerships with professionals to increase awareness and understanding of SMS.
Newly Diagnosed?
Are you associated with someone who has been newly diagnosed with Smith-Magenis Syndrome?
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Sign up to get the latest information and resources from PRISMS and the Smith-Magenis Syndrome community.
Connect with other local families
Connect with your local Regional Representative to help connect you with other SMS families in your area.
You are embarking on a difficult journey, but one that is rewarding.
You will grieve when your child struggles, but you will revel in their accomplishments.
What is SMS?
Smith-Magenis syndrome (SMS) is a rare neurobehavioral disorder characterized by a recognizable pattern of physical, behavioral, and developmental features. It is caused by particular genetic changes on chromosomal region 17p11.2, which contains the gene RAI1. MORE >
What Treatment is Available?
There are no medications that can “cure” SMS or eliminate the core symptoms. However, there are medications that can help some people with SMS function better. For example, medication might help manage high energy levels, inability to focus, or seizures. MORE >
How Rare is SMS?
Although the exact incidence is not known, it is estimated that SMS occurs in about 1/15,000 to 1/25,000 births. SMS is under-diagnosed, but as awareness of the syndrome increases, the number of people identified grows each year. MORE >
How is SMS Diagnosed?
The diagnosis of Smith-Magenis Syndrome (SMS) is usually confirmed through a clinical blood test called a chromosome analysis. Diagnosis can also be made through a cytogenetic test and FISH (fluorescence in situ hybridization) or by chromosome microarray analysis (CGH). MORE >
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Recent SMS News
The Journey Towards Advocacy: My Families Story and Exeriences with a Child with Late Diagnosed Smith-Magenis SyndromeBy: Sabine Cuthill My name is Sabine Cuthill and I am the older cousin to an amazing girl with Smith-Magenis syndrome. Growing up in a hectic French-Canadian household our family dinners and holidays were always…
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From Bowling to Pickleball: One Family’s 15-Year Journey Supporting PRISMSAustin Farber and the winning pickleball team Fifteen years ago, Jeremy and Sylvia Farber turned their family’s journey with Smith-Magenis syndrome (SMS) into a mission to give back. In 2010, they launched their first Bowling…
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